Exosome for GSM
EXOSOME FOR GSM
1. Mesenchymal Stem Cells (MSCs) are multipotent stromal (connective tissue) cells that can self-renew and differentiate into various cell types. Main sources are from bone marrow, adipose tissue, and the umbilical cord (Wharton’s jelly, cord tissue). Exosomes are nano-sized extracellular vesicles (30–150 nm) secreted by MSCs. They carry bioactive molecules such as proteins, lipids, mRNAs, and microRNAs that mediate the therapeutic effects of MSCs — without using live cells. They act like FedEx for cells, delivery messengers to the cells, and guiding tissue repair exactly where it’s needed. Compared to MSCs, they are safe, more stable, and more scalable.
2. Recent studies from two different labs have verified that exosomes derived from human umbilical mesenchymal stem cells (hucMSCs) can significantly increase the viability of human vaginal epithelial VK2 cells and primary human vaginal fibroblast cells, and reduce their apoptosis through MicroRNAs in Vitro. Moreover, exosomes can significantly increase vaginal fibroblast contraction and collagen secretion in vitro. DOI: 10.1093/humrep/dey344; DOI: 10.4252/wjsc.v16.i6.708
3. Another study has demonstrated that exosomes vaginal delivery significantly increases the thickness of the vaginal epithelium layer and the expression of markers for proliferation and angiogenesis in the post-menopausal rat model, which has great translational value for human GSM. DOI: 10.18632/aging.205302
